Interacts with AMBRA1 thereby inhibiting autophagy (PubMed: 21358617). Interacts with BECN1 thereby inhibiting autophagy in non-starvation conditions (PubMed: 18570871, 21358617). Interacts with IRF3 the interaction is inhibited by Sendai virus infection (PubMed: 25609812). Interacts with GIMAP3/IAN4, GIMAP4/IAN1 and GIMAP5/IAN5 (By similarity). Interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (PubMed: 17418785). Interacts with G0S2 this interaction also prevents the formation of the anti-apoptotic BAX-BCL2 complex. Interacts (via the BH4 domain) with EGLN3 the interaction prevents the formation of the BAX-BCL2 complex and inhibits the anti-apoptotic activity of BCL2. Interacts with RAF1 (the 'Ser-338' and 'Ser-339' phosphorylated form). Interacts with BAG1 in an ATP-dependent manner. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 and TP53BP2. Part of a complex composed of SEPTIN4 isoform ARTS, XIAP and BCL2, within the complex interacts (via BH3 domain) with SEPTIN4 isoform ARTS and XIAP, SEPTIN4 isoform ARTS acts as a scaffold protein and stabilizes the complex (PubMed: 29020630). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (PubMed: 8183370, 25609812). Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L).Size: 239 amino acids Molecular mass: 26266 Da Quaternary structure: SP1 POLR2A BCL11A ZNF207 ZNF592 MAZ RCOR1 TARDBP TRIM22 SIN3A HSALNG0122032 BCL2 VPS4B SERPINB12 PHLPP1 lnc-KDSR-6 HSALNG0122031įANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPERĬEBPG JUND MBD2 GATA3 TCF7L2 PKNOX1 FOXA1 HDGF ATF4 TOE1īCL2 SERPINB12 HSALNG0122036 piR-38051-139 HSALNG0122034 PHLPP1 SP1 POLR2A DPF2 KLF17 JUND CTCF ZNF600 BCL11A YY1 REST EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |